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Tumor-infiltrating lymphocytes
Tumor infiltrating lymphocytes (TILs) are a type of white blood cell found in tumors. TILs are implicated in killing tumor cells, and the presence of lymphocytes in tumors is often associated with better clinical outcomes.
==Adoptive cell transfer therapy==
The use of TILs as an adoptive cell transfer therapy to treat cancer has been pioneered by Dr. Steven Rosenberg at the National Cancer Institute. Autologous lymphocytes are isolated from patients’ tumors and grown to very large numbers of cells ''in vitro''. Prior to TIL treatment, patients are given nonmyeloablative chemotherapy to deplete native lymphocytes that can suppress tumor killing. Once lymphodepletion is completed, patients are then infused with TILs in combination with interleukin 2 (IL-2). Lion Biotechnologies is currently developing adoptive cell transfer with TILs for the treatment of cancer.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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